The Inhibition of Phosphoribosyl-pyrophosphate Amidotransferase Activity by Cordycepin Monophosphate.

نویسندگان

  • F ROTTMAN
  • A J GUARINO
چکیده

I. Cordycepin monophosphate has been shown to inhibit the activity of phosphoribosyl-pyrophosphate amidotransferase (ribosylamine-5-phosphate:pyrophosphate phosphoribosyltransferase (ghitamate-amidating), EC 2.4.2.14) obtained from both pigeon liver and Bacillus subtilis. 2. Evidence is presented for the existence of a phosphorylated derivative of cordycepin in Bacillus subtilis cells which were grown in the presence of cordycepin. 3These results, accompanied by previous evidence, suggest that the inhibition of this enzymatic reaction may be the mechanism by which cordycepin inhibits the growth of Bacillus subtilis. ,

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عنوان ژورنال:
  • Biochimica et biophysica acta

دوره 89  شماره 

صفحات  -

تاریخ انتشار 1964